Emerging research indicates a robust, replicable association between joint hypermobility (including Ehlers-Danlos syndromes [EDS] and hypermobility spectrum disorders [HSD]) and several psychiatric conditions, particularly attention-deficit/hyperactivity disorder (ADHD) and depression. However, current evidence supports correlation rather than causation, with multiple plausible mechanisms including shared genetic liability, neurodevelopmental overlap, autonomic dysregulation, and the psychological burden of chronic…